Experimental hypothermia; respiratory and blood pH changes in relation to cardiac function.

PT' EMPORARY whole-body hypothermia in theory offers an ideal way of greatly 1, reducing metabolism, and seems to hold great promise in clinical surgery. Yet, although the reptile or the hibernating mammal can withstand very low body temperatures without distress, body temperatures much below 28°C produce severe and often fatal physiological stress in the non-hibernating mammal. In the course of a series of studies of the physiology of experimental hypothermia in the dog, we have observed profound changes in the auto-regulation of respiration and of blood PH. These changes appear to be important components body temperatures of in the stress effect of low higher mammals. Prevention or control of these changes appears to greatly increase vive extremely the ability of the dog to low body temperatures. sur-